The star online (Newspaper)—behind the cage. UMMU AFIFAH FADZIR, ANTI-PROLIFERATIVE PROPERTY OF PORCUPINE BEZOAR EXTRACT ON MELANOMA (A375). Porcupine Bezoar is believed to have medicinal value is very high to the extent that it is called the king of herbs. A lifetime of grasses, herbs, bark, and other vegetation can leave little bits of indigestible matter behind in a porcupine’s digestive tract, where they occasionally congeal into a hard ball called a bezoar. It can be organic or inorganic material and you would expect that it won’t be easy to find. In … PubMed Google Scholar. In: Akhtar MS, Swamy MK (eds) Anticancer plants: natural products and biotechnological implements. Genuine Porcupine bezoar is a medically potent and rare animal gall stone that is commonly found in the stomach region of a porcupine. A porcupine’s diet is wide, varied, and a little hard to digest. The researchers examined e-commerce sites in Indonesia, Malaysia and Singapore for four months in 2019, where they found active for-sale listings for 443 individual bezoars and a large variety of … Fatimah Opeyemi Roheem, PubMed Central  Porcupine dates are also known as porcupine bezoar, a phytobezoar that is formed from the partly digested plant materials or herbs in the stomach of Himalayan porcupine (Hystrix brachyura) [8,10]. Abstract. Shakirah Razali, Porcupine bezoar (PB) is used as folk medicine for various medical conditions including cancer treatment in Malaysia. As the p. 61. Porcupine bezoar (PB) has been previously reported to possess various medicinal properties. Ridhwan Abdul Wahab. Springer, Singapore, pp 19–39, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800, Minden, Pulau Pinang, Malaysia, Chu Shan Tan, Chiew Hoong Ng, Yean Chun Loh & Mun Fei Yam, You can also search for this author in known as porcupine bezoar, a phytobezoar that is formed from the partly digested plant materials or herbs in the stomach of Himalayan porc( Hystrix brachyura )[8, A traditional folk medicine in Malaysia: porcupine bezoar. However, its potential as an anticancer agent against human cancers is still poorly studied and understood. Google Scholar, The Star Online-Newspaper (2015) Medicine shops claim wildlife products a ‘cure-all’. Hence, in this study, porcupine bezoar (PB) aqueous extract was evaluated for … 1 No. World J Gastroenterol 20(29):9952–9970, Article  Alfi Khatib, The widespread use of the bezoar as an alternative medicine for treatment of deadly illnesses in Malaysia was passed down from generations of the multi-diverse ethnicity environment that existed here. Tanzin Nippun Sharmin, The IC50 result for A375 was found to be 10.1 µg/mL ± 0.17. Hence, in this study, porcupine bezoar (PB) aqueous extract was evaluated for its potential as a safe anticancer agent. MUHAMMAD FARID JOHAN, The main focus of this review paper is on the porcupine bezoar which can be found in Malaysia. Samsul Draman, The data from this study suggest the potential alternative use of PB in developing natural antioxidants and anti-proliferative agents for improving human health. Retrieved from https://www.thestar.com.my/news/nation/2015/08/05/medicine-shops-claim-wildlife-products-a-cureall/#Zv1MlFF3CiX0VwqB.99, Wang DQH, Carey MC (2014) Therapeutic uses of animal biles in traditional Chinese medicine: an Ethnopharmacological, biophysical chemical and medicinal review. Al’aina Yuhainis Firus Khan, Later I found out that bezoar is a mass of food, usually from consuming grass and herbs, found trapped in an animal’s stomach system and is historically used in Chinese traditional medicine. Habibah Hassan, A traditional folk medicine in Malaysia: porcupine bezoar Authors (first, second and last of 4) Chu Shan Tan; Chiew Hoong Ng; Mun Fei Yam; Content type: Review; Published: 28 March 2019; Pages: 131 - 136 Porcupine bezoar (PB) is used in traditional medicine for various medical conditions. Qamar Uddin Ahmed, PubMed  Porcupine bezoar was found in the gastrointestinal tract of porcupine and made up of indigestible plant matters. It was reported as universal medicine in ancient time. The manuscript was designed and written by Tan Chu Shan. It is said that when a porcupine is wounded or sick, it will look for herbs to heal itself. The anti-inflammatory. One of the traditional folk medicine in the Malaysia is using porcupine bezoar. Nanyang Siang Pau. CAS  Porcupine bezoars (PBs) are masses of undigested calcareous concretions formed within the gastrointestinal tract. The selling price of the porcupine bezoar in Malaysia market is around RM300–RM1000 for 500 mg. © 2020 Springer Nature Switzerland AG. Tax calculation will be finalised during checkout. Porcupine dates are also known as porcupine bezoar, a phytobezoar that is formed from the partly digested plant materials or herbs in the stomach of Himalayan porcupine (Hystrix brachyura) [8, 10]. A study published recently in the journal Global Ecology and Conservation tracked, for the first time, the online trade in old-world porcupines (those from the family Hystricidae in Asia and Africa). However, its potential as an anticancer agent against human cancers is still poorly studied and understood. International Islamic University Malaysia, Understanding of Anti-Cancer Properties of Neolamarckia cadamba Leaves Extract on Breast Cancer Cell, INTERNATIONAL JOURNAL OF ALLIED HEALTH SCIENCES: Vol. Pharmacogn Res 9(4):366–371, Article  A case report [ 43 ] has explained that porcupines which had bezoars suffered clinical signs of weight loss, diarrhea, and depression. 1 (2017): Special Issue: Enhancing Academic and Research Quality, CYTOTOXICITY OF LEUKEMIC CELLS BY NYPA FRUTICANS THROUGH REGULATION OF ADIPONECTIN EXPRESSION, INTERNATIONAL JOURNAL OF ALLIED HEALTH SCIENCES: Vol. Natural antibodies Faizah Abdullah Asuhaimi, The bezoars found can be either round or elongated with peel like an Mohammad Syaiful Bahari Abdull Rasad. This manuscript described has not been published before; not under consideration for publication anywhere else; and has been approved by all co-authors. Part of Springer Nature. ATHIRAH ROSDI, Interestingly, the scientific proofs of the usage of bezoar were limited. Ibrahim Abuga, Electroporation (EP) is a technique whereby the biophysical changes on the cells that induced external high-intensity electrical field pulses in order to enhance applications in the medical field. Genuine Porcupine Bezoar Date. It was reported as universal medicine in ancient time. Immediate online access to all issues from 2019. Alaina Yuhainis Firus Khan, https://www.thestar.com.my/opinion/online-exclusive/behind-the-cage/2015/06/12/not-a-miracle-cure/, http://www.animalinfo.org/country/malaysia.html, http://www.enanyang.my/news/20160512/%E7%AE%AD%E7%8C%AA%E6%9E%A3%E4%B9%8B%E8%BF%B7%E6%80%9D%E5%88%98%E6%99%93%E8%88%AA/, http://www.iucnredlist.org/details/10749/0, https://www.thestar.com.my/news/nation/2015/08/05/medicine-shops-claim-wildlife-products-a-cureall/#Zv1MlFF3CiX0VwqB.99, https://doi.org/10.1007/s13596-019-00370-4. Porcupine Bezoar Medical Value According to Chinese medicine records, our ancestors and some aborigines have knowledge on the medicinal values of the porcupine bezoar. Ridhwan Abdul Wahab. Contact Mr.Syaiful +6281389891852 , +601116377848 Porcupine Bezoar Medicinal Values According to Chinese medicine records, in tradition, Porcupine Bezoar had been used as medicine by hill tribes in Southern China and South-East Asia. Google Scholar, Wong LP, AbuBakar S (2013) Health beliefs and practices related to dengue fever: a focus group study. A porcupine bezoar stone is a mass of food found in the stomach believed to treat diabetes, hepatitis, and dengue fever. Google Scholar, Yew PN, Goh BH, Lim YY, Lee WL (2018) Gastrointestinal bezoar stones: current knowledge and future perspective on the potential of plant-derived phytobezoar in cancer treatment. Bezoar porcupine benefits in medicine. SUHANA MAMAT. The bezoar itself is a medical illness (gastrolith) for porcupines and needs to be surgically removed for the porcupine to survive. Ridhwan Abdul Wahab, However, its toxicity profile has never been thoroughly ascertained to confirm its safe nature as an efficacious traditional medicine in the treatment of cancer as well as other ailments. All authors read and approved the final manuscript. Alaina Yuhanis Firus Khan, E-ISSN 2550-147X Porcupine bezoar Apoptosis Cell cycle arrest Anti-angiogenesis Anti-metastasis ABSTRACT Porcupine bezoar (PB) is a calcified undigested material generally found in porcupine’s(Hystrix brachyura) gastrointestinal tract. It is herbivore. Issue 4, December 2020 View all volumes and issues. Alaina Yuhanis Firus Khan, Porcupine Bezoar, Klang. Shakirah Razali, Arch Pathol Lab Med 104:159–161, CAS  It has a coat of sharp spines that defend them from predators. Demand for bezoars isn’t the only threat porcupines face. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Firus Khan, Al'aina Yuhainis and Jalal, Tara Kamal and Abdull Rasad, Mohammad Syaiful Bahari and Hashim, Ridzwan and Abdul Wahab, Ridhwan (2016) Porcupine bezoar exhibit as anti-cancer activities on human breast adenocarcinoma cells (MCF-7). Azir Salleh, PLOS Negl Trop Dis 7(7):e2310, Article  Subscription will auto renew annually. Ancient book of Chinese medicine have been recorded, porcupine bezoar has benefits such as, 1. Pharm Hist (Lond) 43(1):13–22, Endangered animals of the world (2006) Animal info—Malaysia. Faizah Abdullah Asuhaimi, Ridhwan Abdul Wahab. Porcupine bezoar (PB) has been previously reported to possess various medicinal properties. Shaida Fariza Sulaiman, Porcupine Bezoar is a type of stone-like organic substance found in a porcupine’s body. Orient Pharm Exp Med 19, 131–136 (2019). Old Chinese medical text had recorded the used of Porcupine Bezoar. Ridzwan Hashim, Porcupine bezoar is undigested concretions of organic or inorganic which calcified and can be found in gastrointestinal tract of porcupine (Malayan hystrix) [7]. There are undocumented claims that PBs have antioxidant activity and can treat cancers. Porcupine Bezoar Extract (PBE) has been previously described to possess diverse medicinal properties. In this study, porcupine bezoar is highlighted as potential anticancer agents. However, its toxicity profile has never been thoroughly investigated to verify its safety nature. Learn more about Institutional subscriptions, Bao SH (2014) 重镇化痰可治瘟病-箭猪枣非治百病. Habibah Hassan, The selling price of the porcupine bezoar in Malaysia market is around RM300–RM1000 for 500 mg. Porcupine bezoar (PB) has been previously reported to possess various medicinal properties. Malaysia Oriental Daily Newspapar. 3 (2019): Special Issue: Research Towards Sustainable Development Goals, ANTIBACTERIAL EVALUATION OF Curcuma longa, Punica granatum AND Terminalia catappa EXTRACTS, Hystrix brachyura BEZOAR: AN IN VIVO TOXICITY EVALUATION USING EMBRYO ZEBRAFISH (DANIO RERIO) MODEL. 3 No. JOURNAL OF BIOMEDICAL AND CLINICAL SCIENCES, 1 (Special Issue). It is a mass of ingested wild medicinal herbs and plant parts stored inside the porcupine’s internal digestive or system. Adv Biotechnol Microbiol 5(1):555651, Lim AX (2015) 60% Artificial Porcupine Bezoar (豪猪枣60%仿冒). PubMed  2 (2017): Regular Issue, Cancer Chemoprevention Study of Luffa Aegyptiaca Seed Extract on Human Breast Cancer Cell Lines (MCF-7), ANTIOXIDANT, ANTICANCER AND GCMS ANALYSIS OF PORCUPINE BEZOAR AQUEOUS EXTRACTS: A COMPARATIVE STUDY BASED ON MODERN AND CONVENTIONAL EXTRACTION TECHNIQUES, INTERNATIONAL JOURNAL OF ALLIED HEALTH SCIENCES: Vol. Acta med Hist Adriat 12(1):77–98, Brown V (2015) Not a miracle cure. CAS  The materials were collected by Loh Yean Chun. This bezoar has been a myth to the locals. Ng Chiew Hoong participated in the design of the study and performed the statistical analysis. The bezoar is traditionally used in South East Asia and Europe for the treatment of cancer, poisoning, dengue, typhoid, etc. Porcupine date is a rare "stone" that found in the stomach of a porcupine. Correspondence to Chu Shan Tan. The chemical profile and the medicinal properties of the bezoar is still unknown. Folia Zool 62(3):232–234, Article  Ridhwan Abdul Wahab. https://doi.org/10.1007/s13596-019-00370-4, DOI: https://doi.org/10.1007/s13596-019-00370-4, Over 10 million scientific documents at your fingertips, Not logged in A Bezoar is a mass trapped in the stomach comprising some indigestible substance ingested by the human or animal. et al. A bezoar is a mass found trapped in the gastrointestinal system, though it can occur in other locations. Retrieved from http://www.orientaldaily.com.my/s/74980, Liu XH (2016) The mystery of porcupine bezoar (箭猪枣之迷思). Alfi Khatib, * I speak from my own experience. This is a preview of subscription content, log in to check access. Their meat is considered a delicacy in countries such as Thailand, Vietnam, and Malaysia. A porcupine’s diet is wide, varied, and a little hard to digest. There are several varieties of bezoar, some of which have inorganic constituents and others organic.The term has both a modern (medical, scientific) and a traditional usage. Medicinal value of porcupine date and porcupine bezoar Based on the ancient medical books, porcupine belly, meat and glitch have medical value and are able to treat various diseases. This bezoar has been a myth to the locals. PubMed Central  MOHAMMAD FAUZAN ZAINUDIN, RIDHWAN ABDUL WAHAB, Retrieved from http://www.animalinfo.org/country/malaysia.html, Holloway WD, Lee SP, Nicholson GI (1980) The composition and dissolution of phytobezoars. Latest articles. Ridzwan Hashim, - 128.199.74.47. Yes, eating the (real) porcupine dates can help our body to fight and cure a lot of illness. Google Scholar, Yew PN, Lee WL, Lim YY (2017) Antioxidant and intracellular reactive oxygen species/reactive nitrogen species scavenging activities of three porcupine bezoars from Hystrix brachyura. Retrieved from http://www.enanyang.my/news/20160512/%E7%AE%AD%E7%8C%AA%E6%9E%A3%E4%B9%8B%E8%BF%B7%E6%80%9D%E5%88%98%E6%99%93%E8%88%AA/, Lunde D, Aplin K, Molur S (2008) Hystrix brachyura, Malayan Porcupine. volume 19, pages131–136(2019)Cite this article. This quick miracle cure is also perceived to cure cancer, epilepsy, and typhoid.This preternatural or morbid concretions formed in the bodies of porcupines are composed of several layers that look like an onion. A porcupine’s diet is wide, varied, and a little hard to digest. 712 likes. Later, PB aqueous extract was subjected to A375 (Skin Malignant Melanoma) (IC50, cell proliferation assay) and HGF-1 (normal cell, for cytotoxicity assay) to evaluate its anticancer potential. Tan, C.S., Ng, C.H., Loh, Y.C. The IUCN Red List of Threatened Species. Suppliyer porcupine stone / porcupine bezoar. It is a molecular biology technique in order to create pores through a cell wall membrane, boost the permeability of the cell membrane, and support chemicals, drugs or DNA to be imported into Hela cells. Qamar Uddin Ahmed, Porcupine is a mammalian that live in forests. Retrieved from http://www.guangming.com.my/node/237350, Barroso MDS (2014) The bezoar stone: a princely antidote, the Tavora Sequira Pinto collection-Aporto. Google Scholar, Khan FAY, Nasir MMH, Jalal T, Razali S, Hassan H, Asuhaimi FA, Wahab RA (2017) In vitro evaluation of porcupine bezoar extracts as anticancer agent on A549—a preliminary study. PDF | Porcupine bezoar (PB) has been previously reported to possess various medicinal properties. Retrieved from https://www.thestar.com.my/opinion/online-exclusive/behind-the-cage/2015/06/12/not-a-miracle-cure/, Duffin CJ (2013) Porcupine stones. Retrieved from http://www.iucnredlist.org/details/10749/0, Mori E, Sforzi A (2013) Structure of phytobezoars found in the stomach of a crested porcupine, Hystrix cristata L., 1758. 1 No. Volume 20. Initially PB was infused in water for 18 h to get PB aqueous extract which was preliminary tested for total phenolic content (TPC), total flavonoid content (TFC), DPPH activity in order to confirm the presence of bioactive agents as antioxidants in PB. 2. A pseudobezoar is an indigestible object introduced intentionally into the digestive system.. Alfi Khatib, In summary, no, there there is no clinical evidence that Porcupine Bezoar cures cancer or other serious medical illness. Oriental Pharmacy and Experimental Medicine Hence, in this study, porcupine bezoar (PB) aqueous extract was evaluated for … Tara Jalal, IC50 for DPPH was found to be 0.79 μg/mL ± 0.07. Tara Jalal, RIDZWAN HASHIM, Hence, the present study was performed to study PB aqueous extracts (PBAE) in vivo toxicity effects using the zebrafish embryo model. Porcupine Bezoar stone is a type of globular stone-like mass occasionally Produced in a porcupine’s internal body. PB aqueous extract showed significant anti-proliferation pattern at 24, 48 and 72 hours exposures. However, limited scientific study has been carried out to verify these traditional claims. However, its potential as an anticancer agent against human cancers is still poorly studied and understood. PubMed  Latest issue. It is believed by some that the porcupine bezoar stone can be used to cure cancer, diabetes, dengue, typhoid, epilepsy, hepatitis and many more. PB aqueous extract showed 11.68 μg/mL ± 0.67 TPC value while TFC was not detected confirming the absence of flavonoids in PB aqueous extract. Guang Ming Daily Newspaper. In order to cure bulging diseases, residue in the porcupine can be made into powder and consume with warm wine. Journal metrics 89 days Submission to first decision 200 days Submission to acceptance 16,094 (2019) Downloads. Additionally, porcupine bezoar was also known as lifesaver and used by patients with terminal illness. One of the traditional folk medicine in the Malaysia is using porcupine bezoar. Azir Salleh, Dr Yam Mun Fei conceived and supervised the whole project. FIRUS KHAN, A. Y., ABDULLAH ASUHAIMI, F., JALAL, T., NATTO, H. A., ROHEEM, F. O., AHMED, Q. U., JOHAN, M. F., HASHIM, R., & ABDUL WAHAB, R. (2017). ( 1980 ) the bezoar is still poorly studied and understood study suggest the potential alternative use of in... Not a miracle cure verify its safety nature Bao SH ( 2014 ) the of... Stored inside the porcupine bezoar which can be organic or inorganic material you... Its safety nature South East Asia and Europe for the porcupine ’ s diet is wide, varied, depression. 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